Protopine hydrochloride ( —— )

产品货号. M30941 CAS No. 6164-47-2

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产品名称

Protopine hydrochloride
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本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.
产品描述

Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors.
体外实验

Western Blot Analysis Cell Line:HepG2, Huh7 Concentration:10, 20, 40 μM Incubation Time:24 h Result:Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level.Induced the release of mitochondrial protein cytochrome c into the cytosol.
体内实验

Animal Model:5-hydroxy-DL-tryptophan (5-HTP)-induced mice model Dosage:5, 10, 20 mg/kg Administration:i.p.Result:Increased the number of 5-HTP-induced head twitch response (HTR).Decreased the immobility time tested in the Tail suspension test (TST).
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